Why COLLAGEN SYNTHESIS?
Collagen’s main role is to provide structure, strength, and support throughout the body.
Collagen is an essential protein that helps maintain the structural health of the body’s many tissues. Its production is influenced by age, hormones, and diet. Around age 30, collagen production begins to decline, and the first visible signs of aging start to appear. Hormones like estrogen can stimulate collagen synthesis, while a diet rich in protein, vitamin C, and copper supports it.
HUmineral introduces our latest healthy LIVEstyle product — Collagen Synthesis — loaded with nutrient-dense, food-based, health-giving benefits.
HUmineral Collagen Synthesis is swimming in a bed of:
- organic aloe vera (inner leaf)
- structured water
- organic tremella mushroom
- organic amla (Indian gooseberry)
- organic biotin (from holy basil and sunflower seed)
- organic horsetail
- MSM
- organic Irish sea moss
- and hyaluronic acid
Each ingredient is delivered in a proprietary blend of cranberry, wild black cherry, white grape, and pomegranate juice. Mm mm — healthy and good!
The Foundation of Collagen
Collagen is the most abundant protein in your body, making up roughly 30% of total protein. It’s the primary structural building block of skin, muscles, bones, tendons, ligaments, and connective tissues. It also supports organs, blood vessels, and the intestinal lining.
There are several types of collagen, but the three most common are:
- Type I – found in skin, bones, and tendons
- Type II – found in cartilage
- Type III – found in skin, blood vessels, and organs
There are many different sources of collagen protein. You can get it in animal, such as meat, poultry, fish, eggs, animal bone broth and now HUmineral vegan sourced collagen – Collagen Synthesis.
Our mission has always been and still is HEALTH first. HUmineral began with food-based Humic/Fulvic minerals, sharing the importance of mineral nutrition. The body requires minerals like zinc, copper, and manganese, along with other nutrients, to produce collagen. These minerals act as cofactors in the collagen-building process — one reason a diet rich in minerals and nutrients is essential for efficient, natural collagen production.
Answer Your Skin’s Call for Collagen
Why HUmineral Collagen Synthesis?
Aminos
Amino acids are essential building block material for collagen production, acting as part of the raw materials the body needs and uses to build and repair the collagen/protein. Key amino acids like proline, glycine, and lysine are critical for forming collagens structural integrity, ensuring its strength and elasticity, and other specific amino acids play vital roles in maintaining cellular repair and production of other collagen proteins like elastin.
The HUman body uses 20 standard amino acids, the building blocks of proteins. The body can make 11 of these, called non-essential amino acids which are; alanine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, proline, serine, and tyrosine. Non-essential amino acids are produced by the body.
The remaining 9, known as essential amino acids, which are; histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine, must be obtained through diet. Essential amino acids cannot be made by the body and must be obtained from food.
The Amino Acids RECAP
The standard 20 amino’s that make up proteins are: alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine. Remember these amino acids differ based on their unique chain and have various functions within the body, such as building structural tissues like collagen. All are important.
Key amino acids, particularly glycine, proline, and lysine, are necessary building blocks for collagen. Vitamin C is essential for hydroxylation, while copper is needed for cross-linking. This is why MINERALS are important.
As many of our HU healthy followers know our signature start was and is minerals, specifically, Humic/Fulvic Mineral which contains not only copper but vital other minerals, such as calcium, magnesium, selenium, gold, molybdenum, and over 89 others the body requires for proper functioning. The most important fact about HUmic – it knows where and how your body needs to use it – only up taking what the body needs and can use.
A steady supply of all essential amino acids is requisite for optimal health and collagen synthesis. Deficiencies can negatively impact health.
Collagen proteins are made from amino acids. The main amino acids that make collagen are proline, glycine and hydroxyproline. These amino acids group together to form protein fibrils in a triple helix structure (like a binding tie). Your body also needs the proper amount of vitamin C, zinc, copper and manganese to make and form the triple helix. Isn’t this all fascinating – the body is literally a miracle machine with all these extremely complex and intricate little cubby holes.
What is a Triple Helix?
A defining feature of collagen, a three-stranded helical structure, which can refer to a type of protein found in collagen or a three-stranded nucleic acid (DNA or RNA), crucial for the formation of tissues like skin and bone.
What are Fibrils/Fibers/Fibrous?
Collagen fibers are fibrous proteins that provide structural support and strength to various tissues and organs in the body. Collagen fibers are composed of three protein chains (alpha chains) that intertwine to form a triple helix. These triple helixes then assemble into larger bundles called fibrils; fibrils then organize into bundles called fibers (a net).
Mm. Confusing. Collagen fibrils, fibers, and fibrous are not all the same. They are various differing levels of organized collagen structure.
Collagen is a fibrous protein, meaning it’s a type of protein with a long, narrow shape. Fibrils are the smaller, individual filaments that make up collagen fibers. Fibers are formed by bundles of these fibrils and are visible with a light microscope, while a fibrous structure is a general term for a thread-like or elongated shape, which can also refer to a type of connective tissue composed of these fibers. Yep, the body is a gifted machine, made up of a wonder of complexities. Do you BELIEVE?
The Genes/Genetics of COLLAGEN:
The genes we inherit determine the amount and quality of collagen our bodies will produce. We show signs of aging due to the declining collagen production in our bodies naturally. Some of this aging can absolutely be prolonged by simply making our own healthy choices. Work out, eat well and really good nutrient supplementation.
Most notable aging occurs with wrinkles forming, dryness in our skin and hair, teeth discoloration, eye brownness and other signs of bodily aging changes being the most visible. However, other aging processes are going on with the body when collagen production is decreasing.
Fibroblasts are the primary cells responsible for synthesizing collagen, a process that requires the amino acids proline and hydroxyproline, and the vitamin C.
Within the fibroblast, the endoplasmic reticulum and Golgi apparatus are crucial for processing procollagen into the final collagen fibers, which are then secreted outside the cell for assembly. Fibroblasts are essential for wound closure and tissue regeneration. They migrate to the site of injury, produce ECM proteins, and stimulate the proliferation of other cells involved in the healing process. After an injury or disease, fibroblasts help remodel the damaged tissue by adjusting the composition and organization of the ECM. Fibroblasts contribute to the maintenance of tissue homeostasis by regulating the turnover and degradation of ECM components and they interact with immune cells and play a role in modulating inflammatory responses.
A little about transcription and translation in the body, as it relates to collagen. Perhaps we thought collagen production was easy peasy.
Transcription and Translation?
Transcription
- DNA: Template containing the collagen gene sequence.
- RNA polymerase: Enzyme responsible for synthesizing the mRNA strand from the DNA template.
- Transcription factors: Proteins that regulate the activation and modulation of collagen gene transcription.
- Ribonucleotides: The building blocks of mRNA.
Translation
- mRNA: The messenger molecule carrying the genetic code from the nucleus to the cytoplasm.
- Ribosomes: The cellular machinery (composed of ribosomal RNA and proteins) that reads the mRNA sequence.
- tRNA (transfer RNA): Molecules that bring the correct amino acids to the ribosome.
- Amino acids: The building blocks of the protein (collagen polypeptide chains).
- Enzymes and cofactors: Various molecules, such as magnesium, zinc, ferrous iron, and vitamin C, are needed for the synthesis and subsequent post-translational modifications (like hydroxylation) of the collagen chains.
Once the initial polypeptide chains are formed, they undergo extensive post-translational modifications and assembly within the endoplasmic reticulum and Golgi apparatus to form the final, functional collagen protein structure. While the final protein (collagen) is a structural component of the extracellular matrix and essential for tissue integrity, it does not participate directly in the fundamental process of gene expression itself.
A bit about Hydroxylation and Glycosylation
Collagen protein chains needs certain changes, such as adding hydroxyl groups to proline and lysine and attaching sugars to some hydroxylysine residues, so they can fold, stay stable, assemble, and be secreted properly.
Hydroxylation
Hydroxylation takes place in the endoplasmic reticulum, where the enzymes prolyl hydroxylase and lysyl hydroxylase add hydroxyl groups. These enzymes require iron, 2-oxoglutarate, oxygen, and vitamin C to function. If there is not enough vitamin C, collagen does not get enough hydroxyl groups, which can cause scurvy and weak collagen. Again, we see how important Vitamin C (AMLA Indian Gooseberry) is to health.
- Structural Role: Hydroxyproline residues, mainly 4-hydroxyproline in the Y position of the Gly-X-Y sequence, are essential for forming hydrogen bonds and water bridges between chains. These bonds make the collagen triple helix much more stable at body temperature. Hydroxylysine residues act as sites for glycosylation and are important for cross-linking outside the cell, which gives collagen fibrils their final strength.
Glycosylation
- Enzymatic Process: Glycosylation means adding galactose or glucose-galactose disaccharide units to certain hydroxylysine residues. This happens in the ER and Golgi apparatus, with the help of galactosyltransferase and glucosyltransferase enzymes.
- Structural and Functional Role:
Secretion and Assembly: Glycosylation helps proteins fold correctly and acts as a quality control signal for chaperones in the ER. These changes make it easier for the three procollagen chains to form a triple helix and move from the ER to the Golgi, and then out of the cell.
- Supramolecular Structure: Different types of collagens have different amounts of glycosylation, which affects the size and arrangement of collagen fibrils in the extracellular matrix. For instance, basement membrane collagens such as type IV have more glycosylation than fibrillar collagens like type I.
- Molecular Interactions: These sugar groups affect how collagen interacts with other parts of the extracellular matrix and with cell surface receptors such as integrins. This is important for cell signaling and keeping tissues healthy.
In summary, these changes after protein synthesis are essential for collagen to be processed correctly, which keeps its structure strong and allows it to work properly in connective tissues.
A short introduction to the TRIPLE HELIX STRUCTURE and CROSS-LINKING in COLLAGEN
The collagen triple helix is made of three polypeptide chains, each forming a left-handed polyproline II helix, that twist together into a right-handed superhelix. This shape is held together by repeating glycine amino acids, which help keep the helixes tightly packed. Hydrogen bonds between the chains and a high amount of proline and hydroxyproline also help stabilize the structure. The triple helix is non-stretchable along its length, giving it the strength needed to handle the physical stresses our bodies face.
Modified collagen chains come together to form a triple helix, creating procollagen. Fibroblasts then release procollagen into the extracellular matrix (ECM).
The extracellular matrix is a network of proteins and carbohydrates that surrounds and supports the cells in your tissues.
Maturation and Cross-Linking
Collagen maturation is the process of organizing collagen fibers to make them stronger, mainly through cross-linking. Enzymes such as lysyl oxidase help form these cross-links during development, connecting collagen and elastin to stabilize connective tissues. This careful process creates strong, stable collagen structures.
In the ECM, enzymes further process procollagen by removing the end peptides, which creates mature collagen fibers. These fibers are then cross-linked to form a strong, stable network.
Have you ever thought – if I give my body the right nutrients, it will make its own collagen? Guess what, it will! Keep in mind that collagen supplements may not work as well as your body’s natural collagen production when you eat the right foods. The body has to break down what we give it and it must work harder if we feed it what it does not actually need.
HUmineral Collagen Synthesis is loaded with ingredients that help your body make its own collagen naturally, without animal protein, factory farming, or harming the environment. All ingredients come from foods that support a healthy lives span.
What are the Benefits of Collagen you ask?
Collagen can improve the health of your skin, joints, bones, tissues, hair, and nails.
Collagen helps reduce wrinkles, improves skin elasticity and hydration, and protects your skin from sun damage and harsh weather, no matter where you live. It also helps lubricate your joints, bones, and tendons, supports injury repair, and reduces inflammation that can cause pain from arthritis and other issues. Collagen strengthens bones, helps prevent osteoporosis, and gives support and resilience to your hair and nails.
Remember, achieving excellent health takes some effort. We hope we’ve made it a bit easier for you to get the nutrients you need.
Our mission continues.
Answer Your Skin’s Call for Collagen
HUmineral Collagen Synthesis
From the Earth + For All Life
Support your body’s natural collagen production with a potent blend of organic nutrients designed for whole body wellness—from the inside out. This plant-based liquid formula is packed with vitamins, minerals, and botanicals that hydrate, nourish, and help you glow. Think of it as nutrient-rich support for healthy skin, joints, hair, nails, and cellular vitality.
- 100% Natural, Chemical-Free
- Non-GMO
- Free from Gluten, Soy, Dairy, Nuts, Wheat, Sugar
- No animal products — Cruelty Free
- Made in the USA
- 32 fl oz (32 servings)
